Understanding the Causes and Implications of Endothelial Metabolic Variation in Cardiovascular Disease through Genome-Scale Metabolic Modeling
نویسندگان
چکیده
High-throughput biochemical profiling has led to a requirement for advanced data interpretation techniques capable of integrating the analysis of gene, protein, and metabolic profiles to shed light on genotype-phenotype relationships. Herein, we consider the current state of knowledge of endothelial cell (EC) metabolism and its connections to cardiovascular disease (CVD) and explore the use of genome-scale metabolic models (GEMs) for integrating metabolic and genomic data. GEMs combine gene expression and metabolic data acting as frameworks for their analysis and, ultimately, afford mechanistic understanding of how genetic variation impacts metabolism. We demonstrate how GEMs can be used to investigate CVD-related genetic variation, drug resistance mechanisms, and novel metabolic pathways in ECs. The application of GEMs in personalized medicine is also highlighted. Particularly, we focus on the potential of GEMs to identify metabolic biomarkers of endothelial dysfunction and to discover methods of stratifying treatments for CVDs based on individual genetic markers. Recent advances in systems biology methodology, and how these methodologies can be applied to understand EC metabolism in both health and disease, are thus highlighted.
منابع مشابه
فاکتورهای عملکرد اندوتلیال و پروفایل لیپیدی در زنان و مردان مبتلا به سندرم متابولیک
Background & Aims : The metabolic syndrome (MS) is a clustering of risk factors of metabolic origin that increases the risk for cardiovascular disease . Endothelial function biomarkers and lipids profile determine cardiovascular disease . Aim of this study was to investigate the effect of sex on endothelial function and lipid profile. Materials & M ethods: The present study involved 77 pa...
متن کاملPrevalence of Metabolic Syndrome in Patients with Periodontal Disease
Background & Aims: Metabolic syndrome is composed of interrelated cardiovascular and cardiometabolic risk factors. Moreover, recent researches have illustrated the association of systemic diseases and periodontitis. Thus, the early diagnosis of this syndrome, as a cardiometabolic risk factor, seems necessary. The aim of this study was to evaluate the prevalence of metabolic syndrome in patients...
متن کاملEVALUATION OF METABOLIC PROFILE OF PLASMA AMINO ACIDS IN DIABETIC PATIENTS WITH CARDIOVASCULAR DISEASES
Background: Diabetes mellitus is one of the most common endocrine diseases. Cardiovascular disease (CVD) is one of the leading causes of death in patients with type 2 diabetes. The aim of this study was to investigate the metabolic profile of plasma amino acids in diabetic patients with cardiovascular disease. Methods: The present study is a descriptive-analytical cross-sectional study on 140 ...
متن کاملEndothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases
متن کامل
Effect of Resistance Exercise and Training and Principles of Prescribing it for Cardiovascular Patients
Introduction: The importance and necessity of preventing the occurrence of these diseases in order to maintain and promote health, has attracted the attention of many researchers to methods of preventing the occurrence of cardiovascular injury. Metabolic effects of muscle mass loss due to the natural aging process are caused by decreased muscle activity and lead to high prevalence of obesity, i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2016